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Secondly, Holo-Lf also alleviates tumor hypoxia by decomposing the abundant H 2 O 2 in the TME into oxygen, thereby reversing radiotherapy resistance [267]

Mechanistically, under the action of ultrasound, this system not only exhibits traditional CAT-like and POD-like activities to modulate ROS levels but also facilitates macrophage polarization from the pro-inflammatory M1 phenotype to the regenerative M2 phenotype [Figure 9C]

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These results suggest that GSH may have a direct effect on VD metabolism

Oral supplementation retains measurable activity in gastric-origin animal models, reflecting the peptide's natural stability within the gastrointestinal environment

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