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10.1086/525289 Physiol

Furthermore, some cancer cells can develop resistance to oxidative stress, making antioxidant therapy less effective

Exposure of A549 cells to either GSH or NAC (10 mM) significantly increased intracellular GSH concentration

Patients with CFTR mutations can present with pancreatic insufficiency with malnutrition, biliary liver disease, male infertility, intestinal obstruction and other gastrointestinal problems, delayed development, and respiratory conditions (e.g., sinusitis and bronchitis)

Consequently, restoring redox equilibrium represents a promising avenue for overcoming therapy resistance and advancing targeted anticancer strategies that exploit the inherent redox vulnerabilities of malignant cells [33]

Rapoport JL, Gogtay N