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Preclinical and clinical trials should be designed accordingly, with a focus on conditions where antioxidant therapy is more likely to yield therapeutic benefit

Further substantiating the central role of Nrf2 in the anti-inflammatory activity of 15d-PGJ 2 , Bretscher et al

All quantitative safety findings derive from animal and in-vitro models

Because the biological half-life of dexamethasone is 3654 h, we considered overlapping prescriptions, wherein dexamethasone was prescribed within 7 days before the prescription of fluoroquinolone

ATP production from oxidative phosphorylation, glycolysis, and other pathways is critical to support cellular physiology, but this molecule also has signaling properties, which can be particularly beneficial in epithelial cells [70]

However, in these studies, most LAAS were strokes due to extracranial atherosclerosis (ECAS), while it is unclear whether the findings are applicable in strokes due intracranial atherosclerosis (ICAS)