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Points of departure were converted from administered animal doses to human equivalent doses (HEDs) using a standard body weight scaling factor (based on human body weight of 70 kg) in accordance with USEPA guidance (USEPA 2005a)

DOI: 10.3389/fimmu.2024.1310443

Studies have shown that environmental chemicals can disrupt the carefully orchestrated androgen-dependent processes essential for normal sperm development, from spermatogonial stem cell maintenance through final sperm maturation (68)

In this regard, the GIP and GLP-1 agonist, tirzepatide, currently shows promising data derived from phase 2 and 3 clinical trials

For patients requiring long-term treatment, hydrogel carriers can provide continuous drug release and reduce the frequency of administration

This variability directly impacts product quality and stability