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However, discussing a single mechanism may neglect other targets of auxiliary intervention since the function of NAD+ itself is also an important part of the mitochondrial respiratory chain, wherein it interacts with most of the intracellular molecules

SUPPLEMENTARY INFORMATION: Addenda Available Only Through the internet on the CMS Website: The PFS Addenda along with other supporting documents and tables referenced in this final rule are available on the CMS website at

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In addition, signaling pathways such as NF-B, MAPKs, and Keap1-Nrf2-ARE etc., which affects physiological functions of ROS, are also discussed in details