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concurrently, single-cell and spatial transcriptomic analyses of human cardiovascular tissues will be crucial for resolving cellular heterogeneity and defining cell typespecific contributions

Exp Gerontol 38:199206 Skene DJ, Vivien-Roels B, Sparks DL, Hunsaker JC, Pvet P, Ravid D, Swaab DF (1990) Daily variation in the concentration of melatonin and 5-methoxytryptophol in the human pineal gland: effect of age and Alzheimers disease

Tripterygium hypoglaucum Hutch (THH) extract significantly restored the dysbiosis of regulates gut C57BL/6 mice with AIA, with an increase in Bifidobacterium, Akkermansia, and Lactobacillus , and a decrease in Butyricimonas, Parabacteroides, and Anaeroplasma significantly alleviated swollen ankle, joint cavity exudation, and articular cartilage destruction in AIA mice (Zheng et al., 2023

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Acute long duration resistance exercise (180 min of bilateral knee extensions at 55% 1RM) in elderly populations is typically accompanied by an acute inflammatory immune response characterized by the release of interleukin-6 (IL-6) into the circulation (Steensberg et al., 2002)