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Volitinib, SAR125844, and PHA665752 have anti-proliferative and pro-apoptotic effects by inhibition of RAS/MAPK and PI3K/Akt signaling pathways

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Luciferase-expressing MES28 ( c ) or GSC2907 ( d, e ) GSCs were intracranially injected into nude mice (n = 10 per group), and mice were treated with or without 10 mg/kg CWJ C3 (5 days per week), or 5 Gy IR at day 9, 16, and 23 or 20 mg/kg TMZ 5 days per week

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Hillare et al