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In humans, the key enzymes catalyzing this step for the different chain lengths of fatty acids are very long-chain acyl-CoA dehydrogenase (VLCAD), medium-chain acyl-CoA dehydrogenase (MCAD) and short-chain acyl-CoA dehydrogenase (SCAD) [4]

However, larger and longer-term studies are needed to confirm the results

TMAO is a microbial metabolite originating from dietary sources rich in choline and carnitine

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and the extension of immune cells lifespans by reducing apoptosis, or programmed cell death

HPLC also has one of the lowest limits of detection, or LOD, compared to other methods for TMA analysis [9]