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At the C-terminus of the TRPC, TRPM, and TRPA1 subfamilies, the coiled-coil (CC) domain appears to play a role in ligand anchoring and assembly of these channels in the lipid bilayer (Feng, 2017

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During breast cancer, tumor cells recruit resident fibroblasts [57], adipocytes [58], and/or bone marrow-derived mesenchymal stem cells [59], transforming them into cancer-associated fibroblasts (CAFs), which in turn reshape and remodel the tumor microenvironment

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