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So it's interesting because when you hear creatine, it really, it sounds like an amino acid

Nature 447 , 11301134 (2007)

Several studies chose to validate their defined signatures in a secondary dataset and noted improved prediction of outcomes when metabolic biomarkers were used with protein biomarkers (S100b, UCH-L1, GFAP, etc.) [30, 31]

The subsequent formation of PAOs (protein amyloidosis precursorsprotein oligomers) and polymerization deposition lead to the progression of amyloidosis in cardiomyocytes, increasing the risk of AF and heart failure [37, 66, 69]