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Insulin resistance: In high doses or prolonged use, it may slightly alter insulin sensitivity (although the loss of visceral fat may be compensated over a long period of time)

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Its also used off-label for treatment-resistant depression and narcolepsy

The mitochondrial Ca 2+ uptake and the fine-tuning of aerobic metabolism

This increase in permeability was attributed to the rapid activation of the NF-B by IL-1 [18]