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In summary, cellular aging results from a multifaceted interplay of these factors

Mechanisms regulating neutrophil survival and cell death

Damgaard RB

10.1124/jpet.107.129031 J

doi: 10.1093/humupd/dmt015 25 VrbrSTakcsITLNasKSzivaREHetthssyJRet al

The glutamate secretion is sufficient to activate HIF-1 through a paracrine mechanism and inhibits the xCT glutamate-cystine antiporter, causing cysteine depletion, which leads to oxidative self-inactivation of PHD2 and ultimately HIF-1 accumulation [134]