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A phase 2 pilot trial of low-dose, continuous infusion, or "metronomic" paclitaxel and oral celecoxib in patients with metastatic melanoma

However, the activation of NRF2 promotes GPX4 activity and iron storage capacity by increasing the level of GSH and the expression of ferritin heavy chain 1 (FTH1) (Wu et al., 2020)

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[DOI] [PMC free article] [PubMed] [Google Scholar] 56.Kerksick C., Rasmussen C., Lancaster S., Magu B., Smith P., Melton C., Greenwood M., Almada A., Earnest C., Kreider R

OncoTargets and therapy

Among them, a phase I clinical trial (NCT00985777) provided evidence that Tocotrienol (Vitamin E) may induce apoptosis in PDAC cells