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We note that we are proposing to modify the definition of TPS in our regulations at 42 CFR 412.160 to align with the proposal to modify the TPS range to be 0-110 beginning with the FY 2026 program year as discussed in section V.K.6.b.5 of this proposed rule

The concentrations of the various macrospecies comprise the sum of the concentration of those microspecies that contain the same number of protons, for example in GSH: Determination of the redox potential of the GSSG/GSH system was achieved indirectly, applying a redox couple with a known standard redox potential

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[160] demonstrated that in mice the inhibition of mTOR with rapamycin increased the numbers of effector cells, e.g., nave T and B cells, and innate lymphoid cell populations, whereas the numbers of exhausted T cells were reduced

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