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Lactylation in other diseases Lactylation of histones and non-histone proteins is also linked to other various diseases, including liver diseases such as fibrosis, liver ischemia/reperfusion injury (LI/R) injury, and acetaminophen (APAP)-induced liver injury (AILI), lung fibrosis, acute and chronic kidney injuries, skin injuries such as flap necrosis and hyperplastic scarring, skeletal issues such as osteoarthritis and intervertebral disc degeneration (IDD), and sHLH (Figs

Oxidative stress contributes to status epilepticus associated mortality

the enzyme is also present in extracellular fluids as a glycoprotein.48 Most forms of GPx are tetrameric in structure but GPx4 which is often regarded as phospholipid hydroperoxide is a monomer and differ in substrate specificity

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doi: 10.1136/annrheumdis-2014-206914 56 RothuizenL

Randomized controlled clinical trials and meta-analyses are required to test the actual efficacy of polyphenols, providing continuity and perspective to in vitro and cell culture studies