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The gut microbiome is also essential for serotonin production, and gut microbes acting through short-chain fatty acids have been shown to modulate serotonin production in preclinical and in vitro human models [86]

HIV-1 Tat-mediated microglial activation by impairing mitophagy/autophagy Mitophagy selectively removes damaged mitochondria through a progression from phagophore to autophagosome and then to lysosome, thereby preserving organelle integrity and cellular homeostasis [82]

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Participants who received exenatide also displayed significantly less activation of the brain's reward centers when shown pictures of alcohol while undergoing functional MRI scans

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