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Radiology 1971;101:101-104

The asynchronous variant rs2070600 (Gly82Ser), which is linked to both cancer risk and changes in circulating sRAGE, was used as a surrogate marker in a 2016 Mendelian randomized meta-analysis study [9] to infer a potential causal relationship, suggesting that lowered circulating sRAGE concentrations through genetic mechanisms may increase cancer risk