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*Correspondence: Ritsuko Shimizu, [email protected] Specialty section: This article was submitted to Hematology Oncology, a section of the journal Frontiers in Oncology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

Recent research indicates that, despite their widespread reputation as safe supplements with several health benefits, the excessive or unregulated use of antioxidants may have detrimental effects on sperm function [70]

doi: 10.1016/j.lfs.2020.118356 67 LiaoPWangWWangWKryczekILiXBianYet al

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Mitochondria do not contain catalase and are therefore largely dependent on reduced glutathione and glutathione peroxidases for its antioxidant protection