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It is unclear whether the relationship between these chronic diseases represents overspill of local inflammation from one organ into the systemic circulation, or a systemic inflammatory process affecting multiple organ systems

The main cytokines produced due to the immune response in severe COVID-19 are interleukin (IL)-1, IL-2, IL-6, and tumor necrosis factor (TNF) (Rokni et al., 2020)

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In the context of HCC, dysregulation of the GSH and TRX systems is a common adaptive response to abnormal oxidative stress, which disrupts healthy cell metabolism (Brahma et al