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When megaloblastic anemia develops, vascular congestion increases and periorbital hyperpigmentation occurs

In the present study, this mechanistic interpretation remains provisional, consistent with the planned pairwise comparisons showing no significant between-concentration differences within either phase

Shi Z, Zheng J, Tang W, Bai Y, Zhang L, Xuan Z, Sun H, Shao C

Curr Drug Metab (2020) 21:107990

More accurate methods such as trans-endothelial electrical resistance (TEER) and electrical cell-substrate impedance sensing (ECIS) should be used in the future for permeability analysis

This accumulation explains why products that perform well initially often plateau or decline in perceived efficacy