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These iron ions instigate oxidative stress reactions, leading to the production of -OH radicals that subsequently target DNA, proteins, and lipid membranes

However, it had lower cytotoxicity than free CPT, which was maybe due to gradual drug release from the polymeric NPs

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When the tumors reached 50-100 mm 3 , the mice were randomly divided into several groups (n=10)

Furthermore, miR-30e-5p and SLC7A11 mRNA levels were enriched in Ago1 and Ago2, namely, the miRNA-induced silencing complexes (miRISCs), in HAECs transfected with miR-30e-5p (Figure 2H), so SLC7A11 mRNA was a bona fide target of miR-30e-5p in ECs