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As bedaquiline mainly undergoes phase one reactions catalysed by CYP3A4, its exposure may be either reduced or increased during co-administration with inducers or inhibitors of CYP3A4 respectively (Sirturo, 2012)

PS exposure, a marker of altered PM asymmetry, was detected as an early event during NET formation, occurring before PM permeabilization

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The key for female application lies in duration control rather than intensity