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Tirzepatide increases insulin sensitivity, as demonstrated in a hyperinsulinemic euglycemic clamp study in patients with type 2 diabetes mellitus after 28 weeks of treatment

The SURMOUNT-1 trial enrolled over 2,500 participants and tested three dose levels against placebo over 72 weeks

It is produced during protein turnover and is excreted almost exclusively by the kidneys, making it a good biomarker for kidney function, particularly GFR

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