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ROS and Ca 2+ regulate the activity of the mitochondrial permeability transition pore (mPTP)

Recently, interest in TMAO has extended beyond the world of marine biology, with a growing body of research linking it to cardiovascular disease (CVD), insulin resistance, renal dysfunction, cancer, stroke, and inflammation in humans (Velasquez et al

468 GroblerCMaphumuloSCGrobbelaarLMBredenkampJCLaubscherGJLourensPJet al

Deficiencies in these nutrients can impair cognitive processes such as attention, memory, and executive function

However, its therapeutic effects exhibit considerable heterogeneity, and its safety profile and overall applicability require further validation

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