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The genus Berberis represents the most extensively distributed natural reservoir of BBR, with its concentration in medicinal plants ranging significantly from 0.05 mg/g to 96.10 mg/g

Excess amounts are secreted in the urine, preventing a toxic build-up

Additionally, changes in the ACC were shown in previous studies [13]

This results in a small fraction of Tylenol being converted into a toxic metabolite known as N-acetyl-p-benzoquinone imine (NAPQI)

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