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Additionally, leflunomide treatment decreased the levels of MMP-1, MMP-9, and cartilage oligomeric matrix protein (COMP) in the serum of patients with RA (290)

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However, replicating this model remains challenging due to its dependence on mutual trust, institutional continuity, and long-term policy support, which require extended periods of coordinated development to establish effectively

Lim YW, Tan WS, Ho KL, Mariatulqabtiah AR, Abu Kasim NH, Abd Rahman N, et al