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DRUG IT must be activated to be a good leaving group Hydroxyl group is a bad leaving group Examples Estradiol Examples Morphine is extensively metabolized into glucuronide conjugate Example of C-glucuronidation Nucleophilic attack Because this H-atom is acidic Sulfation (sulfate conjugation) Occurs primarily for phenols and occasionally for alcohols, arylamines, and N-hydroxy compounds catalyzed by sulfotransferase enzyme