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Radjabzadeh et al

doi: 10.1016/j.clinbiochem.2009.03.008

Short-term increases in transient receptor potential vanilloid-1 mediate stress-induced enhancement of neuronal excitation

Therefore, we treated mouse and human STS cells with CB-839 combined with DKG or glutamate supplementation to determine whether these additional metabolites reversed CB-839 effects on cell growth and survival

The compound's interaction with VEGFR2 triggers rapid autophosphorylation of tyrosine residues 1175 and 1214, essential for subsequent recruitment of adaptor proteins including Grb2 and Shc