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Among these risk factors, blood fluid shear stress is an important factor regulating EC physiology and pathophysiology and atherosclerosis progression

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The following relevant parameters were determined where possible: area under the concentration-time curve from time zero to the last time point (AUC 0-last ) or extrapolated to infinity (AUC 0- ), C max concentration in plasma extrapolated to time zero (C 0 ), terminal elimination half-life (t 1/2 ), volume of distribution (Vd), and clearance (CL)

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