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doi: 10.1042/bj20081386 54 KangKWLeeSJKimSG

Abrogating native -synuclein tetramers in mice causes a L-DOPA-responsive motor syndrome closely resembling Parkinsons disease

Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: the Scandinavian simvastatin survival study (4S)

Timing of administration : Taking tirzepatide at a consistent time each week, preferably when patients can rest if needed, may improve tolerability

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However, both pathways involve four or five catalytic steps, additionally requiring the participation of the key TCA intermediate -ketoglutarate, which might result in limited pathway efficiency