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If you tried that with plain sterile water, the risk of contamination and bacterial growth in the vial after the first use would be high, since theres nothing to prevent bacteria from growing once its opened

HSS Journal The Musculoskeletal Journal of Hospital for Special Surgery.

M., Estes, M

Phase II trial of pemetrexed plus bevacizumab for second-line therapy of patients with advanced non-small-cell lung cancer: NCCTG and SWOG study N0426