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The core of this pathway is constituted by the executioner proteins BCL-2-associated X protein (BAX) and BCL-2 antagonist/killer 1 (BAK1)

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Fujiwara-Tani R, Nakashima C, Ohmori H, Fujii K, Luo Y, Sasaki T, Ogata R, Kuniyasu H (2025) Significance of malic enzyme 1 in cancer: a review

Furthermore, a placebo-controlled randomized trial evaluated the efficacy of folinic acid (5 mg twice daily) for 12 weeks in 19 children aged 310 years (sex distribution not reported) with ASD diagnosed by ADOS, without genetic syndromes, major medical comorbidities, or treatments affecting folate metabolism

OSR, a quinolizidine alkaloid purified from Sophora alopecuroides, has been reported to exert potent antiinflammatory and antioxidative effects in experimental models of hepatic fibrosis, cerebral ischemia, and cancer, highlighting its potential as a multifunctional cytoprotective agent 38,39,40