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Studies have demonstrated that stress can modulate FKBP5 gene expression at the epigenetic level, leading to reduced FKBP5 methylation, particularly evident in CD4 + T cells and localized near chromosome 6p21.31 (365)

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Future research should concentrate on elucidating additional potential exhaustion-related biomarkers, developing novel drugs and therapeutic strategies capable of effectively reversing T-cell exhaustion, and simultaneously optimizing existing immunotherapy modalities such as combined application of epigenetic drugs, precise metabolic interventions, and engineered cell therapies

GST fusion protein aggregates interfere with reproducible proteinprotein interactions and thus undermine the reliability of the GST pulldown experiment

Evid-based Complement Altern Med 10:4287890

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