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MM patients who progressed after daratumumab treatment had elevated levels of the complement inhibitors CD55 and CD59, in agreement with the hypothesis that CDC represents a major mechanism of action for daratumumab and suggesting a mechanism of resistance to CDC-mediating antibodies

Daratumumab and Isatuximab are conventional CD38-specific mAbs, both derived from human CD38-immunized mice

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doi: 10.3390/pharmaceutics15010221 244 SilvaA

SUBCUTANEOUS INJECTIONS Drugs injected into the subcutaneous (fatty) tissue are absorbed slowly because there are fewer blood vessels in the fatty tissue