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Additionally, pathway enrichment analysis further revealed that these alterations corresponded to disruptions in key metabolic routes, including the glucose-alanine cycle, glucose metabolism, beta-oxidation of very long-chain fatty acids, glutathione metabolism, transfer of acetyl groups into mitochondria, and the degradation pathways of branched-chain aminoacids (BCAA) (Figure S3)

Sn phm khng khuyn khch dng cho tr em, ph n c thai hoc ang cho con b

Evidence revealed that endogenous and exogenous IGF-1 administration protects against the onset and progression of diabetic cardiomyopathy [278, 279]

Dai X, Wang D, Zhang J

2 Mechanisms of ferroptosis in ocular tissues 2.1 Dynamic balance of GSH and GPX4 In tissues rich in polyunsaturated fatty acids (PUFAs), such as the retina (13), the GSH-GPX4 axis maintains membrane stability by scavenging phospholipid hydroperoxides (PL-OOH)

Mitochondrial thioredoxin-2/ peroxiredoxin-3 system functions in parallel with mitochondrial GSH system in protection against oxidative stress