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Several biomarkers currently used in clinical practice, such as C-reactive protein (CRP), creatine kinase-MB (CK-MB), and growth differentiation factor-15, have limited applicability due to confounding factors including patient age, genetic background, cardiac comorbidities, and lifestyle [382, 383]

& Shapiro, L

The researchers stated that B12 levels were not detected in the enriched rice (1:100) and that this was due to the very low levels (~ 1 g/100 g)

Efficient clinical trials will require the prior characterization of objective clusters of patients corresponding to different subtypes of the disease