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6.1 Targeting the synergy between -synuclein aggregation and ferroptosis Iron overload accelerates the formation of toxic -syn oligomers, while aberrant -syn expression disrupts iron metabolism and GSH synthesis, thereby creating a vicious cycle that enhances neuronal susceptibility to ferroptosis (Chen et al., 2025)

This can lead to high blood pressure, problems with the aorta or aortic valves, or problems with the electric signals to the heart (such as an abnormal heartbeat, or arrhythmia)

Periodontol 72 (1), 1318

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Disadvantages of the model are the cost, the time involved, the need for specialized facilities, and the employment of guinea-pigs

Obinutuzumab has been used to treat myasthenia gravis, but its application in treating AE is relatively limited