glutathione synthesis rate-limiting step Glutathione Synthesis in Cancer Cells

In autoimmune diseases such as systemic lupus erythematosus (SLE), mitochondrial damage and the release of mitochondrial DNA (mtDNA) into the cytoplasm and extracellular space have been observed [130]

S -adenosylmethionine stabilizes cystathionine -synthase and modulates redox capacity

Normally, almost all glutathione in the mitochondria is reduced glutathione, but in the presence of mitochondrial dysfunction, the proportion of oxidised glutathione increases due to the increased elimination of ROS

A comparison with the structure of glutathione reductase

References Sattler S (2017) The role of the immune system beyond the fight against infection

Based on the review of key role of ROS in the occurrence and development of breast cancer, it is inspired that the changed expression level of GPxs may achieve the therapeutic purpose after determining its clinical significance in breast cancer