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[195] [212] This internalization is mediated by RhoA activation and its downstream effector ROCK, a process that is TAAR1-dependent

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Excessive extracellular glutamate inhibits system Xc , reducing cystine uptake and depleting GSH, thereby promoting ferroptosis

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The input for the computation of the cross correlation was taken from the proteins crystal structure (PDB ID: 3DK9)

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By working smarter, not harder, melatonin can decrease the availabilityof PUFA and therefore cut off the fuel for ROS production and lipid peroxidation

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doi: 10.1056/NEJMra0708126 111 BettegowdaCSausenMLearyRJKindeIWangYAgrawalNet al

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