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However, other researchers have argued that controversial issues exist because GPNA also inhibits other glutamine transporters, such as SLC38A1, and V-9302 is effective even in SLC1A5 knockout models 206,207

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Neuroinflammation is a critical pathological phenotype of AD, and many studies indicate that NLRP3 and TNF- play great roles in neuroinflammation of AD pathology [36, 37]