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These proteins are kinases and phosphatases as downstream signaling cascades trigger many intracellular phosphorylation events

SIRT1 targets both histone and non-histone substrates, including histones (e.g., H3K9, H4K16 31 ) and transcriptional regulators such as p53, 32 FOXO1/3a, 33 PGC-1, 34 LKB1, 35 and NF-B p65, 36 thereby contributing to epigenetic regulation and broader cellular functions

Curcumin inhibits NF-B activation and reduces the severity of experimental steatohepatitis in mice

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