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Disclosures: Or Steg Saban: Nothing to Disclose, Shannon Vandriel: Nothing to Disclose, Desiree Vaz: Nothing to Disclose, Celine Bourdon: Nothing to Disclose, Amrita Mundh: Nothing to Disclose, Vicky Ng: Nothing to Disclose, Simon Ling: Nothing to Disclose, Robert Bandsma: Nothing to Disclose, Iram Siddiqui: Nothing to Disclose, Binita Kamath: Mirum: Consultant, Mirum: Grant/Research Support, Albireo/Ipsen: Consultant, Albireo/Ipsen: Grant/Research Support, Audentes: Consultant 2628 AUTOPHAGY IMPAIRMENT LEADS TO MULTIPLE FORMS OF CELL DEATH IN THE LIVER Hyeonggeug Kim 1 Menghao Huang 1 Sheng Liu 1 Chuanpeng Dong 1 Xiuxiu Yang 1 Barry Stein 1 Jun Wan 1 X Charlie Dong 1 , 1 Indiana University Background: Autophagy is an essential cellular process that facilitates biomaterial recycling and cellular homeostasis