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The RNS produced by host macrophages can, in turn, neutralize this process and inhibit phospholipid peroxidation

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However, a defect in excretion of uric acid can also occur due to medications, such as diuretics, low dose aspirin, or alcohol

Conversely, the levels of pro-inflammatory metabolites, including pimonidazole (pos_2259), PIP (22:3(10Z,13Z,16Z)/PGE2) (neg_3584), 11-dehydro-thromboxane B2 (neg_4449), (Z)-8-tetradecenal (pos_8651), and mocimycin (neg_4758), were substantially decreased (Fig

FITM2 is more widely conserved than FITM1, since yeast, fly, and worm have only orthologues of FITM2