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Survival pathways triggered by peroxynitrite in cells belonging to the monocyte/macrophage lineage

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Generation of chimeric mice with Gpx4-proficient and Gpx4-deficient hematopoietic cells and analysis of blood parameters Female wild-type (wt) recipient mice of 10 to 12 weeks (Taconic Biosciences, Kln) were lethally irradiated with 850 cGy and reconstituted with 10 BM cells from Gpx4 fl/fl ;CreERT2 or Gpx4 wt/wt ;CreERT2 donor mice

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