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(1958) Science 15 471

They catalyzed the conjugation of intracellular glutathione with great varieties of chemicals possessing electrophilic centre and the final GSH-conjugates had increased hydrophilicity which facilitate their further metabolism and elimination

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This susceptibility of complex I to OS might be explicated by the oxidation of thiol (SH) groups of protein and the existence of accessible oxidation sensitive iron-sulfur centers in this complex [74]