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A549 cells were transfected with shACSL4 or shNC and selected with puromycin (2 g/mL)

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Additionally, TMA can be subsequently oxidized to TMAO by the host hepatic flavin monooxygenase 6 , and high blood TMAO levels are associated with cardiovascular events and mortality 7

Therefore, it is tempting to speculate that dysregulation of the circadian clocks in TAMs may have consequences on cancer progression and metastatization

As IDO1 and TDO2 are the key enzymes associated with Trp-catabolism, we examined the levels of IDO1-associated Trp-catabolite Kynurenine (KYN) in the intact, OVX and OVX+E2 groups of animal plasma