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10.1016/S0891-5849(01)00686-4

Molecular and cellular heterogeneity in rheumatoid arthritis: mechanisms and clinical implications

10.1016/S1474-4422(09)70014-6 106 WuB.TengH.ZhangL.LiH.LiJ.WangL.et al (2015)

They are fat-soluble vitamins, meaning they are stored in the body's tissues and can accumulate to toxic levels with excessive supplementation

[166b] Spinal cord motor neurons [210] and SNc dopamine neurons are prone to mild redox dyshomeostasis, mitochondrial dysfunction and protein misfolding during healthy aging, [166b] which become progressively exacerbated by additional pathogenic factors such as genetic mutations, biometal dysregulation (Cu, Fe) or exposure to toxins

Thus, 7 hydroxycholesterol can be acted upon by a C27 hydroxylase and several other peroxisomal enzymes, which shorten the alkyl side chain and add a carboxylic acid function to yield the bile acid chenodeoxycholic acid