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Orally active Epac inhibitor reverses mechanical allodynia and loss of intraepidermal nerve fibers in a mouse model of chemotherapy-induced peripheral neuropathy

Macroscopic photographs were evaluated qualitatively by two independent investigators blinded to group assignments

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FAO not only supports ATP production but also promotes tumor progression, metastasis, and therapeutic resistance by regulating ROS levels, lipid metabolism-related transcription factors such as peroxisome proliferator-activated receptors (PPARs), and components of the AMP-activated protein kinase (AMPK) signaling axis [15, 16]

With the high-quality separation, the metabolites were readily assigned based on predicted molecular formulas without complications due to overlapping of the m/z series from co-eluting metabolites

Targeting antioxidant pathways may therefore offer a novel avenue for CRC treatment in the future