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Wnt ligands bind to Frizzled receptors on the cell surface, resulting in the increased stability of cytoplasmic -catenin, and its subsequent translocation into the nucleus, where it activates the transcription of MITF by interplay with lymphoid enhancer-binding factor 1 (LEF1)/T-cell factor (LEF1/TCF) (26)

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Topical menthol for chemotherapy-induced peripheral neuropathy: a randomised controlled trial in breast cancer

However, the lack of a clearly defined primary molecular target and the complexity of the peptide mixture present significant challenges for mechanistic understanding and clinical translation

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