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Control Rel

Log 2 -transformed normalized intensity values were used for hierarchical clustering

All measurements were taken following the guidelines provided by the manufacturer

Nausea and vomiting are very likely

This dual function allows for real-time monitoring of treatment response, further optimizing combination therapy approaches [203]

These oligonucleotides typically contain at least one region of modified nucleotides that confers one or more beneficial properties (such as, e.g., increased nuclease resistance, increased uptake into cells, increased binding affinity for the RNA target) and a region that is a substrate for RNase H cleavage